Nonspecific orbital inflammation is a diagnosis of exclusion; systemic and pathologic
evaluation is required to rule out specific causes of inflammation and other infiltrative
diseases.
Keywords
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References
- The nonspecific orbital inflammatory syndromes.Surv Ophthalmol. 1984; 29: 93-103
- Orbital inflammatory disease.Semin Arthritis Rheum. 2008; 37: 207-222
- Consensus on diagnostic criteria of idiopathic orbital inflammation using a modified Delphi approach.JAMA Ophthalmol. 2017; 135: 769
- Orbital pseudotumor: histopathological classification and treatment.Ophthalmologica. 1985; 190: 230-242
- Evaluation of classification systems for nonspecific idiopathic orbital inflammation.Orbit. 2012; 31: 238-245
- The classification and management of acute orbital pseudotumors.Ophthalmology. 1982; 89: 1040-1048
- Gene expression profiling and heterogeneity of nonspecific orbital inflammation affecting the lacrimal gland.JAMA Ophthalmol. 2017; 135: 1156
- Zur Diagnostik und Pathologie der Orbitaltumoren.Ber 32 Versamm Ophthal Ges Heidelberg. 1906; 32: 127-135
- Orbital pseudotumor—historical origin and modern relevance.Ophthal Plast Reconstr Surg. 2013; 29: 341-346
- Inflammatory pseudotumor of the orbit.Arch Ophthalmol. 1923; 52: 582-593
- Why “orbital pseudotumour” is no longer a useful concept.Br J Ophthalmol. 1998; 82: 339-340
- Characterization of the molecular biologic milieu of idiopathic orbital inflammation.Ophthal Plast Reconstr Surg. 2011; 27: 251-254
- Idiopathic orbital inflammation: distribution, clinical features, and treatment outcome.Arch Ophthalmol. 2003; 121: 491
- Survey of 1264 patients with orbital tumors and simulating lesions.Ophthalmology. 2004; 111: 997-1008
- Pseudotumor of the orbit.Radiol Clin North Am. 1999; 37: 151-168
- Pediatric orbital pseudotumor: case report and review of the literature.Int Ophthalmol Clin. 1996; 36: 161
- Orbital pseudotumor in the differential diagnosis of pediatric uveitis.J Pediatr Ophthalmol Strabismus. 1992; 29: 59-63
- Pediatric idiopathic orbital inflammation: clinical features of 30 cases.Ophthal Plast Reconstr Surg. 2016; 32: 270-274
- Dacryoadenitis and orbital myositis associated with Lyme disease.Arch Ophthalmol. 2008; 126: 1165-1166
- An unusual presentation of herpes zoster ophthalmicus: orbital myositis preceding vesicular eruption.Am J Ophthalmol. 2003; 136: 574-575
- Orbital myositis following streptococcal pharyngitis.J Paediatr Child Health. 2008; 44: 233-234
- Orbital pseudotumor and Crohn’s disease.Am J Gastroenterol. 1992; 87: 405-406
- Orbital myositis secondary to systemic lupus erythematosus.Acta Ophthalmol (Copenh). 1994; 72: 520-523
- Pseudotumor orbitae and myasthenia gravis. A case report.Arch Ophthalmol. 1980; 98: 1621-1622
- Toll-like receptors in idiopathic orbital inflammation.Ophthal Plast Reconstr Surg. 2012; 28: 273-276
- What is orbital pseudotumor?.Surv Ophthalmol. 1996; 41: 66-78
- Sclerosing orbital inflammation and systemic disease.Ophthal Plast Reconstr Surg. 2012; 28: 107-118
- IgG4-associated orbital and ocular inflammation.J Ophthalmic Inflamm Infect. 2015; 5: 15
- IgG4-related disease in the eye and ocular adnexa.Curr Opin Ophthalmol. 2017; 28: 617-622
- Ophthalmic manifestations of IgG4-related disease: single-center experience and literature review.Semin Arthritis Rheum. 2014; 43: 806-817
- Characteristics, diagnosis and therapeutic strategies for IgG4-related orbital disease.Pharmacol Rep. 2016; 68: 507-513
- Idiopathic orbital pseudotumour.Clin Radiol. 2011; 66: 886-892
- Orbital inflammatory disease: a diagnostic and therapeutic challenge.Eye (Lond). 2006; 20: 1196-1206
- Nonspecific orbital inflammation.in: Perry J.D. Singh A.D. Clinical ophthalmic oncology. 2nd edition. Springer, Berlin2014: 45-53
- Orbital inflammatory disease: pictorial review and differential diagnosis.World J Radiol. 2014; 6: 106
- Diagnostic imaging in patients with orbital cellulitis and inflammatory pseudotumor.Int Ophthalmol Clin. 2002; 42: 133-142
- MR imaging of orbital inflammatory syndrome, orbital cellulitis, and orbital lymphoid lesions: the role of diffusion-weighted imaging.AJNR Am J Neuroradiol. 2008; 30: 64-70
- Extraocular muscle enlargement with tendon involvement in thyroid-associated orbitopathy.Am J Ophthalmol. 2004; 137: 1145-1147
- IgG4-related systemic disease: features and treatment response in a French cohort.Medicine (Baltimore). 2012; 91: 49-56
- Inflammatory modulators and biologic agents in the treatment of idiopathic orbital inflammation.Curr Opin Ophthalmol. 2012; 23: 420-426
- Treatment of severe idiopathic orbital inflammation with intravenous methylprednisolone.Br J Ophthalmol. 2011; 95: 1068-1071
- Intraorbital injection of triamcinolone acetonide in patients with idiopathic orbital inflammation.Arch Ophthalmol. 2007; 125: 1647
- Intralesional corticosteroid injections as treatment for non-infectious orbital inflammation.Orbit. 2018; 37: 41-47
- Immunosuppressive drugs in immune and inflammatory ocular disease.Surv Ophthalmol. 1991; 35: 369-385
- A role for methotrexate in the management of non-infectious orbital inflammatory disease.Br J Ophthalmol. 2001; 85: 1220-1224
- Low-dose methotrexate therapy for ocular inflammatory disease.Ophthalmology. 1992; 99: 1419-1423
- Successful treatment of idiopathic orbital inflammation with mycophenolate mofetil.Am J Ophthalmol. 2005; 140: 916-918
- CyberKnife radiosurgery and rituximab in the successful management of sclerosing idiopathic orbital inflammatory disease.Ophthal Plast Reconstr Surg. 2006; 22: 395-397
- Rituximab therapy for refractory orbital inflammation: results of a phase 1/2, dose-ranging, randomized clinical trial.JAMA Ophthalmol. 2014; 132: 572
- Idiopathic orbital inflammation successfully treated using rituximab in a patient with rheumatoid arthritis.J Rheumatol. 2012; 39: 1485-1486
- Rituximab for the treatment of IgG4-related disease: lessons from 10 consecutive patients.Medicine (Baltimore). 2012; 91: 57-66
- Intraorbital injection of Rituximab in idiopathic orbital inflammatory syndrome: case reports.Rheumatol Int. 2015; 35: 183-188
- Immunosuppression for the uveitides.Ophthalmology. 2018; 125: 193-202
- Treatment of recalcitrant idiopathic orbital inflammation (chronic orbital myositis) with infliximab.Am J Ophthalmol. 2004; 138: 925-930
- Infliximab in the treatment of recalcitrant idiopathic orbital inflammation.Ophthal Plast Reconstr Surg. 2004; 20: 381-383
- Treatment of orbital myositis with adalimumab (Humira).J Rheumatol. 2005; 32: 1374-1375
- Adalimumab for recurrent orbital myositis in Crohn’s disease: report of a case with a 3-year follow-up.J Crohns Colitis. 2011; 5: 265-266
- Adalimumab for orbital myositis in a patient with Crohn’s disease who discontinued infliximab: a case report and review of the literature.BMC Gastroenterol. 2013; 13: 59
- Treatment of pediatric IgG4-related orbital disease with TNF-α inhibitor.Ophthal Plast Reconstr Surg. 2018; 34: e10-e12
- Treatment of chronic orbital myositis with daclizumab.Can J Ophthalmol. 2007; 42: 156-157
- Outcome of tocilizumab treatment in refractory ocular inflammatory diseases.Acta Ophthalmol (Copenh). 2016; 94: e400-e406
- A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab.J Dermatolog Treat. 2004; 15: 280-294
- Etanercept plus standard therapy for Wegener’s granulomatosis.N Engl J Med. 2005; 352: 351-361
- Etanercept (enbrel)-associated inflammatory eye disease: case report and review of the literature.Ocul Immunol Inflamm. 2006; 14: 145-150
- The results of radiotherapy for orbital pseudotumor.Int J Radiat Oncol Biol Phys. 1990; 18: 407-411
Article info
Publication history
Published online: June 16, 2018
Footnotes
Disclosure: The authors have nothing to disclose.
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