Ocular surface squamous neoplasia (OSSN) is a conjunctival tumor that is staged based
on histopathologic analysis according to the eighth edition (2017) of the American
Joint Committee on Cancer’s Cancer Staging Manual.
Keywords
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References
- Ocular surface squamous neoplasia.Surv Ophthalmol. 1995; 39: 429-450
- Ocular surface tumors.Oman J Ophthalmol. 2009; 2: 3-14
- Factors associated with conjunctival intraepithelial neoplasia: a case control study.Ophthalmic Surg. 1990; 21: 27-30
- Epidemiology of ocular surface squamous neoplasia in Africa.Trop Med Int Health. 2013; 18: 1424-1443
- Amin M.B. Edge S. Greene F. AJCC cancer staging manual. 8th edition. Springer, New York2017
- Ocular surface squamous neoplasia - review of etio-pathogenesis and an update on clinico-pathological diagnosis.Saudi J Ophthalmol. 2013; 27: 177-186
- Epibulbar carcinoma.Int Ophthalmol Clin. 1982; 22: 1-33
- Conjunctival and corneal intraepithelial and invasive neoplasia.Ophthalmology. 1986; 93: 176-183
- Late recurrences and the necessity for long-term follow-up in corneal and conjunctival intraepithelial neoplasia.Ophthalmology. 1997; 104: 485-492
- Surgical management of ocular surface squamous neoplasms: the experience from a cornea center.Cornea. 2000; 19: 278-283
- Long-term results of cryotherapy on malignant epithelial tumors of the conjunctiva.Am J Ophthalmol. 1989; 107: 337-340
- Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases.Br J Ophthalmol. 1999; 83: 98-103
- Excision and cryosurgery in the treatment of conjunctival malignant epithelial tumours.Eye (Lond). 2003; 17: 228-232
- In situ carcinoma of the conjunctiva: surgical excision associated with cryotherapy.Clin Ophthalmol. 2013; 7: 1889-1893
- Adjuvant treatment or primary topical monotherapy for ocular surface squamous neoplasia: a systematic review.Arq Bras Oftalmol. 2017; 80: 131-136
- Surgery versus interferon alpha-2b treatment strategies for ocular surface squamous neoplasia: a literature-based decision analysis.Cornea. 2016; 35: 613-618
- Surgical management of conjunctival tumors. The 1994 Lynn B. McMahan lecture.Arch Ophthalmol. 1997; 115: 808-815
- Conjunctival melanoma.Surv Ophthalmol. 1998; 42: 321-350
- Tumors of the ocular surface: a review.Indian J Ophthalmol. 2015; 63: 187-203
- Plaque brachytherapy for the management of ocular surface malignancies with corneoscleral invasion.Clin Exp Ophthalmol. 2009; 37: 577-583
- Nonpreserved human amniotic membrane transplantation for conjunctival reconstruction after excision of extensive ocular surface neoplasia.Eye (Lond). 2006; 20: 351-357
- Amniotic membrane transplantation for reconstruction after excision of large ocular surface neoplasias.Br J Ophthalmol. 2002; 86: 640-645
- Topical chemotherapy for ocular surface squamous neoplasia: current status.Br J Ophthalmol. 2010; 94: 532-535
- Topical chemotherapy for ocular surface squamous neoplasia.Curr Opin Ophthalmol. 2013; 24: 336-342
- Interferon for ocular surface squamous neoplasia in 81 cases: outcomes based on the American Joint Committee on Cancer classification.Cornea. 2013; 32: 248-256
- Surgical versus medical treatment of ocular surface squamous neoplasia: a cost comparison.Ophthalmology. 2016; 123: 497-504
- Conjunctival intraepithelial neoplasia with mucoepidermoid differentiation: a case report of a subtle lesion.Ocul Oncol Pathol. 2015; 1: 278-282
- Mucoepidermoid carcinoma of the conjunctiva: a clinicopathologic study of five cases.Cancer. 1976; 38: 1699-1709
- Clinical presentation of ocular surface squamous neoplasia in Kenya.JAMA Ophthalmol. 2015; 133: 1305-1313
- Ultra high-resolution anterior segment optical coherence tomography in the diagnosis and management of ocular surface squamous neoplasia.Ocul Surf. 2014; 12: 46-58
- Pterygium and associated ocular surface squamous neoplasia.Arch Ophthalmol. 2009; 127: 31-32
- Diagnosis and management of conjunctival and corneal intraepithelial neoplasia using ultra high-resolution optical coherence tomography.Ophthalmology. 2011; 118: 1531-1537
- Recurrence of ocular surface squamous neoplasia treated with excisional biopsy and cryotherapy.Am J Ophthalmol. 2015; 160: 213-219.e1
- Giant ocular surface squamous neoplasia wrapping whole cornea.Eye Contact Lens. 2017; https://doi.org/10.1097/ICL.0000000000000391
- Predictors of ocular surface squamous neoplasia recurrence after excisional surgery.Ophthalmology. 2012; 119: 1974-1981
- Ocular surface squamous neoplasia: analysis of 78 cases from a UK ocular oncology centre.Br J Ophthalmol. 2013; 97: 1520-1524
- Topical fluorouracil after surgery for ocular surface squamous neoplasia in Kenya: a randomised, double-blind, placebo-controlled trial.Lancet Glob Health. 2016; 4: e378-e385
- Pyogenic granuloma developing rapidly after excision of corneal/conjunctival intraepithelial neoplasia.Nippon Ganka Gakkai Zasshi. 2010; 114 ([in Japanese]): 1036-1039
- Ocular surface squamous neoplasia: a standard of care survey.Cornea. 2005; 24: 297-300
- Ocular surface squamous neoplasia: a survey of changes in the standard of care from 2003 to 2012.Cornea. 2013; 32: 1558-1561
- Use of impression cytology for the detection of unsuspected ocular surface squamous neoplasia cells in pterygia.Arq Bras Oftalmol. 2014; 77: 305-309
- In vivo confocal microscopy of ocular surface squamous neoplasia.Eye (Lond). 2011; 25: 455-460
- Optical coherence tomography–current and future applications.Curr Opin Ophthalmol. 2013; 24: 213-221
- Micrometer-scale resolution imaging of the anterior eye in vivo with optical coherence tomography.Arch Ophthalmol. 1994; 112: 1584-1589
- Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases.Ophthalmology. 2011; 118: 1297-1302
- Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia.Ophthalmology. 2012; 119: 481-486
- Role of high resolution optical coherence tomography in diagnosing ocular surface squamous neoplasia with coexisting ocular surface diseases.Ocul Surf. 2017; 15: 688-695
- Topical application of 5-fluorouracil in premalignant lesions of cornea, conjunctiva, and eyelid.Doc Ophthalmol. 1986; 64: 34-42
- Section 8: cornea and external disease. Basic clinical and science course. American Academy of Ophthalmology, San Francisco (CA)2015
- Topical interferon alpha 2b eye-drops for treatment of ocular surface squamous neoplasia: a dose comparison study.Br J Ophthalmol. 2010; 94: 551-554
- Treatment of ocular surface squamous cell intraepithelial neoplasia with and without mitomycin C.Cornea. 2011; 30: 37-41
- Long-term outcomes after adjunctive topical 5-flurouracil or mitomycin C for the treatment of surgically excised, localized ocular surface squamous neoplasia.Clin Exp Ophthalmol. 2014; 42: 317-322
- Diagnosis and medical management of ocular surface squamous neoplasia.Expert Rev Ophthalmol. 2017; 12: 11-19
- Neoadjuvant topical mitomycin C chemotherapy for conjunctival and corneal intraepithelial neoplasia.Eye. 2006; 20: 1092-1094
- Mitomycin C as an adjunct in the treatment of localised ocular surface squamous neoplasia.Br J Ophthalmol. 2004; 88: 17-18
- Treatment of ocular surface squamous neoplasia with mitomycin C.Br J Ophthalmol. 2010; 94: 555-558
- Long-term results of topical mitomycin C 0.02% for primary and recurrent conjunctival-corneal intraepithelial neoplasia.Ophthal Plast Reconstr Surg. 2009; 25: 296-299
- Topical 0.002% mitomycin C for the treatment of conjunctival-corneal intraepithelial neoplasia and squamous cell carcinoma.Cornea. 2005; 24: 443-448
- Topical mitomycin C for extensive, recurrent conjunctival-corneal squamous cell carcinoma.Am J Ophthalmol. 2002; 133: 601-606
- Randomized controlled trial of topical mitomycin C for ocular surface squamous neoplasia.Ophthalmology. 2007; 114: 976-982
- Mitomycin C or interferon as adjuvant therapy to surgery for ocular surface squamous neoplasia: comparative study.Eur J Ophthalmol. 2017; https://doi.org/10.5301/ejo.5001035
- Chemoreduction with topical mitomycin C prior to resection of extensive squamous cell carcinoma of the conjunctiva.Arch Ophthalmol. 2005; 123: 109-113
- Topical 5-fluorouracil in treating epithelial neoplasia of the conjunctiva and cornea.Ophthalmology. 1995; 102: 1338-1344
- Adjuvant 5-fluorouracil in the treatment of localised ocular surface squamous neoplasia.Br J Ophthalmol. 2011; 95: 947-950
- Topical 1% 5-fluorouracil in ocular surface squamous neoplasia: a long-term safety study.Br J Ophthalmol. 2011; 95: 355-359
- Topical 5-fluorouracil 1% as primary treatment for ocular surface squamous neoplasia.Ophthalmology. 2016; 123: 1442-1448
- Management of diffuse ocular surface squamous neoplasia: efficacy and complications of topical chemotherapy.Clin Exp Ophthalmol. 2015; 43: 20-25
- Perilesional and topical interferon alfa-2b for conjunctival and corneal neoplasia.Ophthalmology. 1999; 106: 91-97
- Giant ocular surface squamous neoplasia managed with interferon alpha-2b as immunotherapy or immunoreduction.Ophthalmology. 2012; 119: 938
- Regression of presumed primary conjunctival and corneal intraepithelial neoplasia with topical interferon alpha-2b.Cornea. 2002; 21: 6-11
- Subconjunctival/perilesional recombinant interferon α2b for ocular surface squamous neoplasia.Ophthalmology. 2010; 117: 2241-2246
- Topical interferon or surgical excision for the management of primary ocular surface squamous neoplasia.Ophthalmology. 2008; 115: 1302.e1
- Long-term follow-up of conjunctival and corneal intraepithelial neoplasia treated with topical interferon alfa-2b.Ophthalmology. 2008; 115: 1296.e1
- Topical Interferon α-2b as a single therapy for primary ocular surface squamous neoplasia.Asia Pac J Ophthalmol (Phila). 2015; 4: 279-282
- 5-fluorouracil for the treatment of intraepithelial neoplasia of the conjunctiva and cornea.Ophthalmology. 2000; 107: 2190-2195
- Topical 1% 5-fluoruracil as a sole treatment of corneoconjunctival ocular surface squamous neoplasia: long-term study.British Journal of Ophthalmology. 2017; 101: 1094-1099
- Retrospective comparative study of topical interferon α2b versus mitomycin C for primary ocular surface squamous neoplasia.Cornea. 2017; 36: 327-331
Article info
Publication history
Published online: May 18, 2018
Footnotes
Disclosure Statement: The authors have nothing to disclose.
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