Use of intravitreal melphalan for vitreous seeding in retinoblastoma has allowed for
stable rates of eye preservation without exposing children to external beam radiation
therapy; 100% control of vitreous seeds has been reported.
Keywords
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References
- Retinoblastoma in the 20th century: past success and future challenges the Weisenfeld lecture.Invest Ophthalmol Vis Sci. 2005; 46: 2683-2691
- Retinoblastoma treated with intravenous nitrogen mustard.Am J Ophthalmol. 1953; 36: 1721-1723
- Chemotherapy plus local treatment in the management of intraocular retinoblastoma.Arch Ophthalmol. 1996; 114: 1348-1356
- Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy.Arch Ophthalmol. 1996; 114: 1321-1328
- Chemoreduction in the initial management of intraocular retinoblastoma.Arch Ophthalmol. 1996; 114: 1330-1338
- Systemic chemotherapy: a pediatric oncology perspective.in: Ramasubramanian A. Shields C.L. Retinoblastoma. Jaypee Brothers Medical Publishers, New Delhi (India)2012: 81-85
- Retinoblastoma: achieving new standards with methods of chemotherapy.Indian J Ophthalmol. 2015; 63: 103-109
- Carboplatin-associated ototoxicity in children with retinoblastoma.J Clin Oncol. 2012; 30: 1034-1041
- A retrospective review of hearing in children with retinoblastoma treated with carboplatin-based chemotherapy.Pediatr Blood Cancer. 2008; 50: 223-226
- A phase I/II study of direct intraarterial (ophthalmic artery) chemotherapy with melphalan for intraocular retinoblastoma initial results.Ophthalmology. 2008; 115 (1404.e1): 1398-1404
- Superselective ophthalmic artery chemotherapy as primary treatment for retinoblastoma (chemosurgery).Ophthalmology. 2010; 117: 1623-1629
- Intra-arterial chemotherapy for the management of retinoblastoma: four-year experience.Arch Ophthalmol. 2011; 129: 732-737
- Unilateral retinoblastoma managed with intravenous chemotherapy versus intra-arterial chemotherapy. Outcomes based on the international classification of retinoblastoma.Asia Pac J Ophthalmol (Phila). 2016; 5: 97-103
- Retinoblastoma frontiers with intravenous, intra-arterial, periocular, and intravitreal chemotherapy.Eye (Lond). 2013; 27: 253-264
- Retinoblastoma: evidence for stage-based chemotherapy.Int Ophthalmol Clin. 2015; 55: 63-75
- Supraselective intra-arterial chemotherapy: evaluation of treatment-related complications in advanced retinoblastoma.Clin Ophthalmol. 2011; 5: 171-176
- Delayed cerebral infarction following intra-arterial chemotherapy for retinoblastoma.JAMA Ophthalmol. 2016; 134: 712-714
- Present therapeutic resources in retinoblastoma.Acta Ophthalmol (Copenh). 1961; 39: 569-576
- Profiling safety of intravitreal injections for retinoblastoma using an anti-reflux procedure and sterilisation of the needle track.Br J Ophthalmol. 2012; 96: 1084-1087
- Intravitreal injection of melphalan for intraocular retinoblastoma.Jpn J Ophthalmol. 2015; 59: 164-172
- Risk of extraocular extension in eyes with retinoblastoma receiving intravitreous chemotherapy.JAMA Ophthalmol. 2017; 135: 1426-1429
- The classification of vitreous seeds in retinoblastoma and response to intravitreal melphalan.Ophthalmology. 2015; 122: 1173-1179
- Classification and management of seeds in retinoblastoma. Ellsworth Lecture Ghent August 24th 2013.Ophthalmic Genet. 2014; 35: 193-207
- Chemosensitivity profiles of primary and cultured human retinoblastoma cells in a human tumor clonogenic assay.Jpn J Cancer Res. 1987; 78: 858-868
- Intravitreal topotecan in the management of refractory and recurrent vitreous seeds in retinoblastoma.Br J Ophthalmol. 2018; 102: 490-495
- Combined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma.JAMA Ophthalmol. 2014; 132: 936-941
- Diffuse chorioretinal atrophy after a single standard low- dose intravitreal melphalan injection in a child with retinoblastoma: a case report.BMC Ophthalmol. 2016; 16: 27
- Intravitreal chemotherapy for vitreous seeding in retinoblastoma: recent advances and perspectives.Saudi J Ophthalmol. 2013; 27: 147-150
- Intra-arterial chemotherapy for retinoblastoma in eyes with vitreous and/or subretinal seeding: 2-year results.Br J Ophthalmol. 2012; 96: 499-502
- Efficacy and toxicity of intravitreous chemotherapy for retinoblastoma: four-year experience.Ophthalmology. 2017; 124: 488-495
- Intravitreous chemotherapy for active vitreous seeding from retinoblastoma: outcomes after 192 consecutive injections. The 2015 Howard Naquin Lecture.Retina. 2016; 36: 1184-1190
- Not all seeds are created equal: seed classification is predictive of outcomes in retinoblastoma.Ophthalmology. 2017; 124: 1817-1825
- Intravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.Arch Ophthalmol. 2012; 130: 1268-1271
- Intravitreal chemotherapy for vitreous disease in retinoblastoma revisited: from prohibition to conditional indications.Br J Ophthalmol. 2012; 96: 1078-1083
- Pathological findings in enucleated eyes after intravitreal melphalan injection.Int Ophthalmol. 2014; 34: 533-540
- Local and systemic toxicity of intravitreal melphalan for vitreous seeding in retinoblastoma: a preclinical and clinical study.Ophthalmology. 2014; 121: 1810-1817
- Electroretinogram monitoring of dose-dependent toxicity after ophthalmic artery chemosurgery in retinoblastoma eyes: six year review.PLoS One. 2014; 9: e84247
- Anterior ocular toxicity of intravitreous melphalan for retinoblastoma.JAMA Ophthalmol. 2015; 133: 1459-1463
- Intravitreal melphalan for persistent or recurrent retinoblastoma vitreous seeds: preliminary results.JAMA Ophthalmol. 2014; 132: 319-325
- Toxic effects of melphalan, topotecan and carboplatin on retinal pigment epithelial cells.Acta Ophthalmol. 2016; 94: 471-478
- Acute hemorrhagic retinopathy following intravitreal melphalan injection for retinoblastoma: a report of two cases and technical modifications to enhance the prevention of retinal toxicity.Ocul Oncol Pathol. 2017; 3: 34-40
- Combined intravitreal melphalan and intravenous/intra-arterial chemotherapy for retinoblastoma with vitreous seeds.Graefes Arch Clin Exp Ophthalmol. 2016; 254: 391-394
- Ocular side effects following intravitreal injection therapy for retinoblastoma: a systematic review.Br J Ophthalmol. 2014; 98: 292-297
- Ocular and systemic toxicity of intravitreal topotecan in rabbits for potential treatment of retinoblastoma.Exp Eye Res. 2013; 108: 103-109
- Eye-preservation treatment of retinoblastoma with vitreous seeding.Jpn J Clin Oncol. 2003; 33: 601-607
- Vitreous seeds in retinoblastoma: clinicopathologic classification and correlation.Ophthalmology. 2017; 124: 1540-1547
Article info
Publication history
Published online: May 18, 2018
Footnotes
Disclosure Statement: The authors have nothing to disclose.
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